منابع مشابه
UbcH7 regulates 53BP1 stability and DSB repair.
DNA double-strand break (DSB) repair is not only key to genome stability but is also an important anticancer target. Through an shRNA library-based screening, we identified ubiquitin-conjugating enzyme H7 (UbcH7, also known as Ube2L3), a ubiquitin E2 enzyme, as a critical player in DSB repair. UbcH7 regulates both the steady-state and replicative stress-induced ubiquitination and proteasome-dep...
متن کامل53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair
Increased mobility of chromatin surrounding double-strand breaks (DSBs) has been noted in yeast and mammalian cells but the underlying mechanism and its contribution to DSB repair remain unclear. Here, we use a telomere-based system to track DNA damage foci with high resolution in living cells. We find that the greater mobility of damaged chromatin requires 53BP1, SUN1/2 in the linker of the nu...
متن کامل53BP1 regulates DSB repair using Rif1 to control 5' end resection.
The choice between double-strand break (DSB) repair by either homology-directed repair (HDR) or nonhomologous end joining (NHEJ) is tightly regulated. Defects in this regulation can induce genome instability and cancer. 53BP1 is critical for the control of DSB repair, promoting NHEJ, and inhibiting the 5' end resection needed for HDR. Using dysfunctional telomeres and genome-wide DSBs, we ident...
متن کاملEscort Evolutionary Game Theory
A family of replicator-like dynamics, called the escort replicator equation, is constructed using information-geometric concepts and generalized information entropies and diverenges from statistical thermodynamics. Lyapunov functions and escort generalizations of basic concepts and constructions in evolutionary game theory are given, such as an escorted Fisher’s Fundamental theorem and generali...
متن کاملGeometry of escort distributions.
Given an original distribution, its statistical and probabilistic attributes may be scanned using the associated escort distribution introduced by Beck and Schlögl and employed in the formulation of nonextensive statistical mechanics. Here, the geometric structure of the one-parameter family of the escort distributions is studied based on the Kullback-Leibler divergence and the relevant Fisher ...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2020
ISSN: 0890-9369,1549-5477
DOI: 10.1101/gad.333237.119